Pure EncapsulationsAdenosyl/Hydroxy B12 Liquid 30 mL - Supports Energy Metabolism & Neurological Health* - for Brain Support* - Gluten Free - Vegan - 1 Fl Oz

I got this product after getting my results back from some genetic testing I did and finding out I needed to take B12 sublingually in the adenosylcobalamin form. This has been perfect so far.

You can count on Pure Encapsulations to make a quality product. I keep this in the fridge because we live in a hot climate, but the company says it's stable at room temp for 9 months. Taste is slightly sweet, the product works well. My B12 levels are great.

I don’t usually write reviews but it really helped me to read others’ experiences. There isn’t much information online about adverse reactions or processing from methylcobalamin or cobalamin b12 supplements, which are most of the b12 supplements out there. My experience consisted of having low b12 and needing to supplement but all the supplements would cause lethargy starting about 2-3 hours after I took the supplement which would lead to shoulder/neck then head tension or a migraine. Higher doses would increase the effect and I had nausea a few times. And these would be from very high quality supplements. I even tried food based lower dose (250% DV) ones and still it had that effect to some, maybe a lesser degree. Dessicated liver seems fine but doesn’t raise the levels enough. It has felt like 5 years of a catch 22 of low b12 and feeling low energy so taking a supplement which makes me feel worse, but still needing b12. So anyways, I don’t know if I have a gene mutation or not. I haven’t been taking this form of b12 for very long but the difference was noticeable on day 1. Each serving size has around 41,000% of b12 and the bottle says to take 1-3 servings a day (1mL or one dropperful). I measured that each dropperful has around 20 drops, so if I take 5 drops I’m getting around 10,000%. Literally that’s all I have needed 1x a day, it’s pretty crazy. I stopped drinking coffee over a year ago but this supplement feels comparable to drinking coffee. Lots of energy and productivity and more of a clear head. I think if I took a whole serving size it would be too much energy!! I’m just so happy to feel like I have made a breakthrough with energy and b12.

I need extra b12..especially when anyone has laughing gas at dentist which depletes b12. I’ve had low b12 levels for years and had injections and capsules but this 1000 mg dose is so easy to put in coffee, water, smoothie, etc. I believe this contains the best form of b12 that is best absorbed. I still take a capsule daily that contains folate also which is needed so wish this also contained folate.

While Pure is highly respected for product quality, it's very expensive for 1oz.I limited my doses.

I have homozygous mthfr c677t & ironically Methylated B12 normally gives me major anxiety and jittery feelings and headaches .Figured out I’m definitely over methylating. This form is much better for me. I’m taking an extremely low dose. Since it’s liquid it’s easy to customize my dose down to just a few drops vs a whole dropper.My low b12 and symptoms of it are improving quickly despite the small (tolerable) dose I’m taking. The only side effect was a slight headache the first couple days.So for someone very sensitive like me, this is a great option.Update 7/28/2024: in just as little as 6 weeks of doing these drops (micro dosing basically) my b12 went from low 300s to 670. I stopped supplementing at that point because I noticed that after I’d take it, I’d feel weepy and anxious rather than energetic and focused. I assume just my sensitive body telling me that I didn’t need anymore. This is how you know what’s optimal.I have had several rounds of blood work done since to keep a check on it and my numbers are holding! My low b12 symptoms are gone, and my health & anxiety has improved so much that I’m driving again and not feeling so withdrawn.Really great book suggestions to those considering b12 sups: Dirty genes by Ben lynch and Could it be B12 second edition (I forget the author name.

My 23andMe genetic testing recommended the Adenosyl/Hydroxy form of B12 over the Methylcobalamin form, which I have taken for over 4 years. And I also have the MTHFR gene mutation. Switching to the Adenosyl/Hydroxy made all the difference in the world. Within a few days I felt like a different person, and several unresolved health issues simply seemed to vanish. I feel calm inside, my GERD is 99% cleared up, and my numerous digestive problems are no where to be found. For the first time in 4 years, my abdominal pain and tenderness is gone, and I'm finally able to sleep on my stomach at night. I highly suggest everyone get genetically tested so you'll know the appropriate supplements your body needs. And not to be forgotten is that I am experiencing a HUGE increase in energy and stamina!

High quality and expedient shipment.