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- Doctor's Best SAM-e 400 mg - 60 Enteric-Coated Tablets Doctors Best SAMe contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none. S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones. Features & Benefits: Science-based nutrition Dietary supplement Enhances mood and neural function Promotes joint comfort and mobility Supports liver health and detoxification Supplementing with SAMe The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure S,S form on the market. SAMe and Joint Function SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort. SAMe and Neural Health SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function. SAMe and Liver Function SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins. Potent Promoter of Mood and Cognitive Health After at least 18 controlled human trials, published over almost four decades, SAMe is clearly proven to promote healthy mood. The latest double-blind trial was published in 2010, and its findings were so impressive that the journal also published an editorial in praise of SAMe. This editorial attributed SAMe's marked mood benefits to its diverse roles in brain metabolism. SAMe is essential for the healthy metabolism of the major brain transmitters dopamine, serotonin, and norepinephrine. SAMe is also essential for the main metabolic pathway that makes PC (phosphatidylcholine), a key cell membrane phospholipid for the nerve cell informational connections (synapses). Myelination—insulation of the nerve cell extensions to optimize their electrical conduction—also requires SAMe. And SAMe is also essential for the brain to produce melatonin, a hormone that regulates healthy sleep patterns. Individuals who have mood difficulties often also have problems with memory and other cognitive functions. In a 2010 double-blind trial, SAMe supported cognitive health while promoting healthy mood. SAMe supports the metabolism of acetylcholine, a major nerve transmitter that is essential for attention, learning, and memory and for numerous other functions outside the brain. Even as SAMe ameliorates mood difficulties, SAMe also has improved energy levels, as found in two other double-blind trials. Optimal SAMe intakes for mood and cognitive support are 800-1600 mg per day, preferably as divided doses taken between meals. Promotes Joint Comfort and Mobility A minimum 14 controlled clinical trials prove SAMe is consistently effective for the support of joint comfort and mobility. In the longest trial, which lasted two years, 97 subjects received SAMe at 600 mg per day for the first two weeks, followed by 400 mg per day for the remaining period.n
- UPC # 753950002524
- Size/Form 60 Enteric-Coated Table
Suggested Use: Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet. INGREDIENTS Doctor's Best Double-Strength SAMe 400 - 60 Enteric Coated Tablets Supplement Facts Serving Size: 1 tablet Servings Per Container: 60 Amount Per Serving %DV* S-Adenosyl Methionine (from 800 mg of SAM-e tosylate disulfate) 400 mg + +Daily Value Not Established. **Percent Daily Values are based on a 2,000 calorie diet. Your diet values may be higher or lower depending on your calorie needs. Other Ingredients: Cellulose Gel, Methacrylic Acid Copolymer, Compritol 888ATO, Talc, Triethyl Citrate, Titanium Dioxide, Magnesium Stearate, Mannitol, Glycerol Palmitostearate, Silica, Medium Chain Triglycerides, Sodium Starch Glycolate and Iron Oxide. Suitable for Vegetarians. WARNINGS Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.
