E45 Itch Relief Cream 500G | 24-hour hydration with urea for moisture retention - Relieves itchy skin, perfume free & dermatologically tested

HEAVEN in a bottle 🙌🏽🙌🏽🙌🏽🙌🏽 I have been suffering with eczema on both of my hands, of all places since June 2025 and I have literally tried EVERYTHING.. nothing works. Not even the prescribed medication. Long story short I read a post about E45 on Facebook about the same condition I have. Extreme itching, eczema. Yada Yada.. it hasn’t even been 24 hours. I could cry 😭 I know it’s pricey but it’s worth it!

Bought this for my father in law bc he was itching like crazy!! I think he has excema but won't go get it checked out. He would itch until the point of bleeding. So a friend told me about this cream that helped her. I ordered it and low and behold it worked! He loves it so much the bottle is almost empty and I got it like 6 months ago. It was very effective for him and he stopped itching when he put it on. Will be buying again for him and also no more bleeding thank god!

I've developed a mild eczema on my hands, arms and ankles and got a steroid cream prescription. When traveling home from England, Heathrow confiscated my steroid cream from my purse and forced me to put in my luggage even though a prescription label was clearly affixed to the tube. To try and cope on the flight, I bought a small tube of E45 Itch Relief at the airport drugstore, and was surprised at how it calmed down the red patches on my hands. I used up the tube at work over several months, and amazingly have now got down to using the steroid cream maybe once a month or so with a bad flare up. After reading how steroid cream can cause long term serious side effects, I combine this with a heavy Eucerin emollient on top at night. When the tube ran out, I bought this big 500g jar. I'm terrified to be without it as it has really reduced my use of the steroid cream.

I am a 75 year old female who has been plagued with severe rashless overall body itch for years. It has kept me awake at night and caused extreme anxiety. Up until now the only product that helped was Cerave anti-itch lotion with pramoxine. This was somewhat soothing for an hour or so but not always. An article I read on itchy skin mentioned E45. I researched the ingredients, lauromacrogols and urea, and decided to take a chance. It is a miracle. I have been using it for five days, and in that time I have experienced longer and longer periods of total relief. If I wake in the night with a burning itch, an application of E45 gives me almost immediate relief. Whereas before I had to apply lotion every 3-4 hours 24 hours a day, now I can go with two daily applications about 12 hours apart. I am not saying this will work for everyone; nothing does. But for anyone who is desperate and has tried everything else, I would say give this a shot. It's expensive, but if it relieves the torment then it is cheap.

Amazing. Works wonders on my skin and I have severely dry skin and psoriasis.

Why is this wonderful stuff not available in the US? I was traveling in the UK and broke out in an eczema rash. The brands of lotion I usually buy were not available there, and the pharmacist/chemist recommended this so I bought it. I was dubious, but it worked wonders. It's not thick and filmy feeling like the eczema lotions I have used in the US, which I thought would be a downside in that I wouldn't get lasting itch relief and moisturizing. However, I was surprised that it could be light and relieve the itch for a good while. Also, it seemed to calm my skin so that it wasn't so red. Upon returning to the US, I bought this through amazon. It took a while to ship (which I understand is a common problem from the UK), but was so happy to get it when it arrived.

The cream went on smooth. No noticable odor. I received the swivel top also. It works well. The cream resolved the itching immediately! I use it after my shower on days I know that my eczema is going to ITCH. So far it has been working. My skin is smooth while using Itch Relief cream! Added bonus

Didn't work for me and left my skin burning.

Works great

Really works well make sure you choose the correct product, cream not the cheaper lotion which is a good moisturiser but does nothing for itchy backs. Good dispenser

Great product and good review.

Well I didn’t hold out much hope as nothing so far has taken away my Itching. But OMG as soon as it was applied. It felt cold which was amazing in itself. But the Itch was gone. I’m so happy. I am totally bedbound. I can’t even move by myself. So when I get an itch which I do all of the time. It’s horrible as I can’t reach it and also as my skin is so fragile. Scratching just opens it all up. I can’t sleep at night because of the itching. I can’t describe the feeling if not itching. It’s amazing. Just give it a go. What gave you got to lose. And yes it might be a tad expensive. But a little goes along way. And taking away the itching. I would have paid anything. So to me this is a small price to pay.

This cream should have been delivered today now told it won't be delivered till the 15th no reason given but I'm t0ld can not cancel why