Will this work to back up (time machine etc) a 2020 Mac Mini?

Not sure but it should do. It works perfectly well in my iMac.

Will this work for this pc: 4 cores 8th intel core i5-8259u 3.8ghz beelink mini pc windows 10 16gb ram 512gb nvme m.2 ssd sei8 micro pc

Short answer: No. You need to purchase the NVMe version of this drive.

Has anyone used this in a desktop/laptop? my 256gb samsung is filling up fast on my workhorse desktop and tempted to upgraded with a 1tb or 500gb. tia

I have this installed on my desktop. Primarily for quietness against the noisy hard drives, I still use the hard drives for some data needs. I have had the 500gb version since March, split into system and data. System is still less than half full, even though things like Office 365 reside in there. However, it is the cost that should make you purchase this. Incidentally, never had an issue since installation and the computer remains on, for no real reason.

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Description

🚀 Elevate Your NAS Game with WD Red SSD – Speed, Endurance, and Power in One Compact Drive!

BUILT TO ENDURE NONSTOP - Engineered for relentless 24/7 NAS operation, delivering unmatched endurance under heavy read/write cycles.
INSTANT ACCESS ZERO WAIT - Optimized caching technology slashes latency, making your most-used files instantly available.
FLEXIBLE NAS UPGRADE OPTIONS - Available in 2.5-inch form factor, easily upgrade or customize your NAS setup with WD Red reliability.
TURBOCHARGE YOUR NAS STORAGE - Experience blazing 1 TB capacity with SATA 6 Gb/s speed for seamless large file handling.
POWER YOUR DEMANDING WORKFLOWS - Perfect for multi-user environments, 4K/8K video editing, and OLTP databases—boosting your productivity.

The WD Red 1 TB NAS SSD is a 2.5-inch SATA 6 Gb/s solid-state drive purpose-built for NAS systems. Featuring Western Digital’s 3D NAND technology, it delivers high endurance for 24/7 heavy workloads, optimized caching for rapid file access, and enhanced responsiveness for demanding applications like 4K/8K video editing and multi-user environments. Its compact form factor and robust performance make it the ideal upgrade for professional-grade NAS setups.

Specifications

Brand	Western Digital
Product Dimensions	10.03 x 6.99 x 0.71 cm; 4.25 g
Batteries	1 AAAA batteries required.
Item model number	WDS100T1R0A
Manufacturer	Western Digital
Series	WDS100T1R0A RED SA500
Colour	Red
Form Factor	2.5-inch
Hard Drive Size	1 TB
Hard Disk Description	Solid State Drive
Hard Drive Interface	SATA 6 GB/s
Hard Disk Rotational Speed	7200 RPM
Wattage	60 watts
Power Source	Hand-operated
Hardware Platform	Polycarbonate
Are Batteries Included	No
Lithium Battery Energy Content	2 Kilowatt Hours
Lithium Battery Packaging	Batteries contained in equipment
Lithium Battery Weight	2 Grams
Number Of Lithium Ion Cells	5
Number of Lithium Metal Cells	5
Item Weight	4.24 g
Guaranteed software updates until	unknown

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