Has anyone switched over from Frontline Plus to K9 Advantix II and is happy? For Dogs

YES!!!! I've had the same experience with my dogs as Nicole A replied. I had been pleased with Frontline for years....but in 2012 (and ever since) it has just stopped working. One of my dogs is a fur-making machine: and fleas don't seem to bother him...even if I am finding them on him. The other dog has horrible flea allergies: has immediate, sustained, and severe "hot spots" after even just ONE flea bite...skin will turn pink all over his body...and he "blows" large amounts of his beautiful, lush, scruffy coat...and he just doesn't seem to be his usual happy, bright, and enthusiastic self :-( Using Advantix II....he seems to not have problems at all (it keeps the fleas from breeding...although if one occasional transient flea bites him....it will die...but the dog will still get a "hotspot", but nowhere as intense or sustained as without Advantix II...and if I find it quickly and clean it with vinegar, he may not even need a dose of benedryl). During the "flea season" since using Advantix II he has been able to keep his lush coat with no problems.....to such an extent that I brought him in to my vet's office just to show the vet how well he was doing one summer (the dog had been so bad the previous summer while using Frontline that I had to take him to the vet for skin reactions, fur loss in large areas of his coat, and a secondary infection from scratching...I had been so discouraged about the flea problems that year while on Frontline that I had been taking the dog daily to the lake so he could swim and drown the damned fleas). The vet was very pleased with the dog's condition with Advantix II, and had stated he has learned from his patients that they are also seeing less effectiveness with Frontline in recent years. I won't use anything else but Advantix II during this up-coming flea season. (although I do also spray his coat/skin with vinegar (mixed 1/2 with water) each day as a flea deterrent...especially if he gets a hotspot...and I add a small amount of vinegar to his food as well........and when he does need a bath: I use EXTREMELY diluted Dr. Bronner's castile liquid soap in the "EUCALYPTUS" version....the dog tolerates it well...and it seems the scent repels fleas a bit. I use the soap as well to launder the cover of his dog bed at least weekly). I know that insects can get resistent to certain pesticides over time....and I suspect that is why Frontline no longer works in our area.....I sure hope it doesn't eventually happen with Advantix II as well....and I hope that producers of flea/tick products for dogs will monitor this situation and re-formulate their products as needed to address the situation--regionally if need be.

I thought I was ordering Advantage II but by mistake, ordered Advantix II. What is the difference, and does it work the same?

You can’t use advantix on cats. sadly because advantix 2 is superior and is the best out there because unlike advantage (and unlike frontline) it repels flies and mosquitoes as well as ticks and fleas. but it is toxic to cats. as cats should be indoors only you shouldn’t need tick/mosquito repellent just flea. DO NOT USE ADVANTIX ON CATS! It is toxic to them

What about cats? I used to use Advantix on my cats with no problems, as suggested by my vet to save money. Has the formula changed?

Look at the active ingredients for both the dog & cat formulas; They are exactly the same. Only difference is the dosage size which you can easily look up on the internet & save yourself a ton of money

Could I use this along with a flea/tick collar?

As a vet tech we say a flea collar is basically worthless..At most may keep fleas off pets head. If you can buy flea collar at store probably won’t work and even the script only work minimal. Stick to topical like frontline plus, advantage, advantix and oral like Capstar. Flea collars are most always a waste of $. To remove fleas fast simply bathe dog and let dog sit in water…drowning fleas and follow up in few hours with topical if bad infestation. Just a flea or 2 I’d still bathe but topical probably enough. All topicals are water resistant after 24hr

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Reviews

Y**N

I brought my dog to West Virginia, and thank God for Advantix II — because I’ve been finding half-dead ticks every single day (no joke) in places where she sleeps or rests. At first, I was confused. I thought "repels ticks" meant it would work like bug spray does for mosquitoes, keeping them away completely. But after looking into the active ingredient, permethrin, I realized that in this case, “repel” means: once a tick touches the treated fur, it becomes so irritated or neurologically impaired that it can’t bite, can’t hang on, and eventually just falls off and dies. That’s still so much better than PetArmor, Frontline, or any of the oral preventatives (like Simparica or NexGard), which require the tick to bite the dog before it dies. No thanks. Every tick I’ve found so far had already dropped off my dog before it had a chance to bite her and feed — exactly what you want in a tick-heavy area. I’ve also tried Wondercide (cedar oil). It works okay for fleas, but it’s just not effective for ticks, especially not in the long term. Its protection wears off after 2–4 hours. I learned the hard way — my dog caught Lyme disease, developed joint pain and a limp. Thankfully, doxycycline helped and she’s okay now, but it required a full 28-day antibiotic course. I would never use oral flea/tick medications. Just ask around — you’ll hear plenty of stories about dogs having seizures after taking them. For me, that risk isn’t worth it. If you have a cat at home, unfortunately Advantix II may not be right for your household — permethrin is toxic to cats (especially when wet). But if you don’t have cats, I highly recommend this product to all dog owners. Tick-borne diseases are no joke. Fleas are annoying — I’ve had to go through the nightmare of clearing an infestation — but at least they just suck blood without causing life-threatening illness. Ticks, on the other hand, can transmit Lyme, Ehrlichia, Rocky Mountain spotted fever, and more. So if you live somewhere warm, humid, grassy, or deer-heavy — do your dog a favor and get Advantix II. It’s been a lifesaver for us.

4.06.2025

L**N

Great for my dogs. Great value price on Amazon.

3.03.2026

W**.

works the best during peak season.

20.02.2026

B**Y

Works like it should

7.02.2026

A**R

What we use

8.02.2026

ASIN	B004QRJJ0K
Allergen Information	Crab
Batteries Included	No
Best Sellers Rank	#44,880 in Pet Supplies ( See Top 100 in Pet Supplies ) #55 in Dog Flea Drops
Color	Blue
Customer Reviews	4.6 4.6 out of 5 stars (16,255)
Date First Available	7 August 2012
Flavor	Other
Item Form	Topical
Item Weight	45.4 g
Item model number	81520429
Number of Items	6
Pet Life Stage	Senior
Pet Type	Dog
Product Dimensions	19.69 x 2.54 x 10.8 cm; 45.36 g
Quantity	1
Size	6 Pack
Volume	24 Milliliters
batteries required	No

Bayer K9 Advantix II Flea, Tick and Mosquito Prevention for X-Large Dogs, Over 55 lbs Over 55 lb 5420429

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