Nature Made SAM-e Complete 400 mg, Dietary Supplement for Mood Support, 36 Tablets, 36 Day Supply

Item quality is great. it is the best in my opinion. I have taken it for 10 years and try others from time to time they never work as well.Right now the listing has an error though, when you change the number of pills you order, it also changes the dosage from 400, to 200. I've order the wrong dosage three times because of this :(

Nature Made is the best SAM-e. Can never find it in Walgreens or Rite Aid anymore. Sucks because it was the only way it was affordable when it would be bogo. They don’t even sell the Walgreens or Rite Aid brands anymore I don’t get it. I bought naturemade religiously for over 20 years. I can’t afford it at this price but as long as the expiration date is like 2 years out and it’s fresh, they always made the best one. Enteric coated, empty stomach with B12, B6 & Folic acid. 1200-1600 mg a day for mood. 400-800 for joints and liver detoxification. Miracle supplement.

Love that they are individually wrapped

Great buy at works but I am taking two 400 mg tabs daily.Is up to you what works for you

Best of them all.

May be a placebo but it’s working for me. Takes irritably down a notch and makes my energy level higher. I take them usually first thing in the morning with a glass of water.

Good product

My review on this needs a little backstory: I've been taking St. Johns Wort for several years for moderate depression and anxiety. It has changed my life; however, I began to worry about its counteractive effect on birth control. I don't want to use standard pharmaceuticals unless I absolutely have to, so I decided to try Sam-E.Effects of Sam-E on mood: Definite mood boost. Never sank into the very low spots that plagued me before.On energy: Insane energy levels. Useful, but a little scary. For several hours after I took it I was buzzing.On sleep: Gave me moderate insomnia. Again, I didn't feel tired, but not being able to sleep at night was frustrating.On urine?!: Bright highlighter yellow. Florescent pee. That was weird.On stomach: This is where it really got me. I took it after waking up, so empty stomach, and ate 40 minutes to an hour later. For the first week it gave me INTENSE stomach pain for about four hours after taking it. After that first week, the intense pain subsided to a dull ache, but - sorry for the graphics here - it gave me diarrhea every. single. day. Not so good. But since it worked so well at lifting my fatigue, I kept trying it, until week 5...On brain: When the dizziness set in. My brain started swirling around so vigorously I couldn't walk or drive. I actually kept taking it for a week after the dizziness started, because the mental clarity it had given me before was so useful. I didn't want the Sam-E to be the cause. But at week 6 I double checked the list of side effects for Sam-E and yes indeed, dizziness is on it. I switched back to St. Johns and in the weeks since the dizziness has slowly faded away.So, that was a long review, but I wanted to really share my experience. The upsides of Sam-E are very powerful, and since everyone's body reacts a bit differently, it's almost certainly worth a shot if you have anxiety, depression, and fatigue. If Sam-E doesn't work for you, I can recommend from my experience St. Johns Wort. It doesn't give the energy boost but it is a great mood balancer and has never messed with my stomach. I've also heard that 5-HTP can work well for some people, so you might give that a try too.I hope you find something that works for you! Just don't give up and assume that depressed is the only way you can be. As strange as it seems, taking a little plant pill or an enzyme really can be the thing that sets your brain right and gets you on a brighter path. It won't solve all your problems but it can help keep your mind from sabotaging you at every step. :) Good luck.